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When substituting clonidine transdermal system for oral clonidine or for other antihypertensive drugs, physicians should be aware that the antihypertensive effect of clonidine transdermal system may not commence until 2 to 3 days after initial application.
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One controlled trial suggests that among those with adhd and comorbid tics the combination of clonidine and methylphenidate is superior than either drug as a standalone treatment.
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